Reach Us 44-7456-871389

Abstract

Plasma Cyclophilin-A as a Novel Biomarker in Chronic Nephropathy

Background: Type 2 diabetes mellitus (DM) is the most common cause of end- stage renal disease. Albuminuria is the foremost commonly ƵÆ?ůŝÇ?Ä?Ä? marker to Ä?nÆ?cŝÆ?Ä?Æ?Ä? onset of Ä?ŝÄ?bÄ?Æ?c nephropathy (DN) without ƐƵĸcŝÄ?nÆ? Ä?Ä«Ä?cÆ?Ä?bŝůŝÆ?Ç? and ƐÆ?Ä?cŝĮcŝÆ?Ç? to ŝÄ?Ä?nÆ?ĨÇ? early DN. Aim: This study aimed to evaluate plasma Plasma cyclophilin A (CypA) as a new biomarker for early DN. Methods: This cross ƐÄ?cÆ?ŽnÄ?ů study included 125 ŐÇ?Æ?Æ?Ä?n subjects Ä?Æ©Ä?nÄ?ŝnŐ the out WÄ?Æ?Ä?nÆ?Ɛ Clinic of the Department of Internal Medicine, 10Th of Ramadan city Health Insurance Hospital and divided into:-control group, Æ?Ä?Æ?Ä?nÆ? with Ä?ŝÄ?bÄ?Æ?c mellitus, Æ?Ä?Æ?Ä?nÆ?Ɛ with ŝÄ?bÄ?Æ?c nephropathy and Æ?Ä?Æ?Ä?nÆ? with Ä?ŝÄ?bÄ?Æ?c nephropathy and other cŽmÆ?ůŝcÄ?Æ?ŽnƐÍ? WÄ?Æ?Ä?nÆ?Ɛ were subjected to measurement of plasma α- Klotho, FBS, HbAIC, serum rÄ?Ä?Æ?nŝnÄ?Í? serum urea, serum uric acid, k, Na, serum phosphorus, Albumin: rÄ?Ä?Æ?nŝnÄ? ZÄ?Æ?ŽÍ? GFR, Chol, TG, LDL HDL, AST, ALT, T.BIL, D.BIL ALB, TP, GLB and A/G rÄ?Æ?ŽÍ? Results: Results showed that plasma a-klotho was ƐŝŐnŝĮcÄ?nÆ?ůÇ? correlated with haemoglobin A1C, potassium, GFR, Albumin, TP and GLB. Meanwhile, plasma a- klotho was nÄ?ŐÄ?Æ?Ç?Ä?ůÇ? correlated with Ä?ƵrÄ?Æ?Žn of DM, CR, Urea, UR.A, Na, phosphorus, ACR, Chol, TG, LDL, AST, ALT, T.BIL, and D.BIL. However, there were no ƐŝŐnŝĮcÄ?nÆ? cŽrrÄ?ůÄ?Æ?ŽnƐ between plasma a-klotho and FBS, HDL and A/G rÄ?Æ?ŽÍ? At cƵÆ?ͲŽī level ≥84.14, cyclophilin A had 91% ƐÄ?nƐŝÆ?Ç?ŝÆ?Ç? and 62% ƐÆ?Ä?cŝĮcŝÆ?Ç? for diagnosing Ä?ŝÄ?bÄ?Æ?c nephropathy. Conclusion: CypA can be used as an early marker for DN as we found early ƐŝŐnŝĮcÄ?nÆ? high levels of urinary CypA in Ä?ŝÄ?bÄ?Æ?c Æ?Ä?Æ?Ä?nÆ?Ɛ with stage 2 DN even before the appearance of albuminuria.


Author(s):

Mohy Eldin Abd EL-Fattah



Abstract | PDF

Share this  Facebook  Twitter  LinkedIn  Google+